The reproducibility and sample size requirements of exercise-induced bronchoconstriction measurements

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The reproducibility and sample size requirements of exercise-induced bronchoconstriction measurements.

Dry air exercise challenges are frequently used to screen medications that have potential utility in the management of exercise-induced bronchoconstriction (EIB). The purpose of this study was to determine the reproducibility of three outcome measurements made using such challenges, and sample size requirements for drug evaluation studies based on these outcomes. Forty adult subjects with asthm...

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Sample size estimation in studies monitoring exercise-induced bronchoconstriction in asthmatic children.

BACKGROUND The repeatability of the response to standardised treadmill exercise testing using dry air and monitoring of heart rate in asthmatic children suffering from exercise-induced bronchoconstriction (EIB) has not been well established. METHODS Twenty seven asthmatic children with known EIB performed standardised exercise testing twice within a period of three weeks. The tests were perfo...

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Is Exercise-Induced Bronchoconstriction Exercise-Induced Asthma?

The article in this issue of RESPIRATORY CARE by Burnett et al1 reports that 34 of 80 college athletes had exerciseinduced bronchoconstriction (EIB), most in the absence of symptoms. The authors further suggest that these athletes are at risk and that the identification of those with EIB may prevent morbidity and mortality. The implication is that the presence of EIB is evidence for asthma. But...

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Exercise-Induced Bronchoconstriction

Exercise-induced bronchoconstriction (EIB) is defined as transient, reversible bronchoconstriction that develops after strenuous exercise. If exercise is the only identified trigger for bronchoconstriction, it is called EIB. However, when it is associated with known asthma, then it is defined as EIB with asthma. The role of atopy in the pathogenesis of EIB has not been determined. In this issue...

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Imitators of exercise-induced bronchoconstriction

Exercise-induced bronchoconstriction (EIB) is described by transient narrowing of the airways after exercise. It occurs in approximately 10% of the general population, while athletes may show a higher prevalence, especially in cold weather and ice rink athletes. Diagnosis of EIB is often made on the basis of self-reported symptoms without objective lung function tests, however, the presence of ...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2001

ISSN: 0000-0000,0903-1936

DOI: 10.1183/09031936.01.17405810